Assess Risk for Estrogen Sensitive Cancers
with the Estronex Profile - a simple at-home urine test
The Estronex Profile measures five important estrogen metabolites and their ratios to help women, and even men, assess whether he or she is at risk of developing estrogen sensitive cancers.
Estrogen sensitive cancers include uterine, ovarian, cervical, prostate, and even head and neck cancers. 
The Estronex Profile measures important estrogen metabolites and ratios, including
The “Good” Estrogen
- 2-hydroxyestrone (2-OHE1) – high levels of 2-OHE1 are ideal to reduce cancer growth.
- 2-methoxyestrone (2-MeOE) – 2-MeOE has shown to have anticancer effects and is ideal in high levels.
- 4-methoxyestrone (4-MeOE) – as a non-cancerous metabolite, 4-MeOE generally does not require treatment at high levels in the body.
The "Bad" Estrogen
- 4-hydroxyestrone (4-OHE1) – considered a “bad” estrogen, 4-OHE1 levels should be low, as high levels may react negatively with damaged DNA.
- 16-α-hydroxyestrone (16α-OHE1) – also considered a “bad” estrogen, 16α-OHE1 in high levels may encourage tumor development.
The Ratios
- 2-OHE1:16α-OHE1 (2:16 ratio) - 2:16 ratios less than 2.0 indicate increasing long-term risk for breast, cervical, and other estrogen sensitive cancers. Importantly, nutritional interventions can help raise Estronex 2:16 ratios and decrease long-term risk. Studies also indicate that this risk is modifiable!
- 2-OHE1:2-MeOE – a high level of 2-OHE1:2-MeOE may also indicate imbalanced estrogen metabolism and low activity in the COMT gene. Evaluation of methylation activity is recommended.
All this can be determined from a single urine specimen.
Advantages of the Estronex Profile:
An easy-to-collect first-morning urine specimen; no blood draw is necessary!
Cost-effective method to assess estrogen metabolism allowing clinicians to retest often to monitor therapy in patients.
Easy to incorporate into a breast cancer prevention program.
Ideal for men to evaluate risk of breast and prostate cancer.
The following may contribute to your risk of developing estrogen-sensitive cancers, including breast, cervical, and prostate cancers:
- Prolonged use of oral contraceptives (5+ years)
- Synthetic hormone replacement therapy
- Family history or personal history of breast cancer
- Obesity or sedentary lifestyle
- Consumption of 2 or more alcoholic drinks per day
- Getting older
- Never having children, or having your first after 30
- Having high breast density on a mammogram
- Being exposed to large amounts of radiation
Every Woman Should Know Her Risk for Estrogen-Sensitive Cancers...
Now you can - with a simple urine test! A test to determine if you
might be at risk...and a plan to reduce that risk.
Why are some women susceptible, but not others?
Researchers at Rockefeller University found that the body metabolizes estrogen into several different forms that can impact cancer development. A woman’s “biochemical individuality” determines how much of each form is produced. Studies have shown that measuring the ratios of these important forms of estrogen provides an important indication of future risk for development of breast cancer and other estrogen-sensitive cancers. The studies also show that this risk can be modified!
An estimated 192,370 new cases of invasive
breast cancer are expected to occur among
women in the US during 2009; about 1,910 new
cases are expected in men.
– Cancer and Statistics, American Cancer Society, 2009
What can I do if my 2:16 ratio is low?
Consume more foods containing indole-3-carbinol (I3C):
- Broccoli
- Brussel Sprouts
- Cauliflower
- Cabbage
Take nutritional supplements containing Diindolylmethane (DIM) - a more stable supplement closely related to I3C
Follow up testing is also strongly recommended to ensure treatment is effective over time.
View a sample report.
How to Get the Test
Your functional test is ordered through me in my capacity as a Certified Nutritionist.
Use our secure online shopping cart.
The test kit with full instructions will be sent to you within a few days. A small shipping and handling fee applies.
Collect the specimens at your convenience and send directly to the independent laboratory.
The test results are sent to me and I will forward a copy to you.
We then schedule a time to discuss the interpretations and implications of the results and possible nutritional and lifestyle treatment programs appropriate for you based on your test results.
You'll have the option of working with me further to treat your results and resolve the problems revealed in your testing.
For questions and tests not available for order online, email maryann@evenstaronline.com
To your health ,
The fee for the
Estronex Panel
functional health test is
$226
